Antemortem Diffusion MRI and Postmortem White Matter Rarefaction

 
   Lead Investigator:    Andreana Benitez
   Institution      :    Medical University of South Carolina
   E-Mail           :    benitez@musc.edu
   Proposal ID      :    1530



   Proposal Description:
   The goal of this project is to examine the correspondence between antemortem and postmortem measures of white matter pathology using diffusion MRI and findings of white matter rarefaction and other neuropathologies, respectively. The results of this study will test the hypothesis that myelin loss and other white matter-related pathologies are key drivers of cognitive decline/dementia.